06/18/2025, 02:51 PM UTC
新型纳米平台克服膀胱癌治疗耐药性Novel Nanoplatform Overcomes Treatment Resistance in Bladder Cancer
➀ 研究人员开发了新型多功能纳米颗粒PPBC LNPs，整合光动力/光热疗法和实时成像，可治疗耐药性膀胱癌；
➁ 该纳米颗粒通过诱导癌细胞死亡和抑制自噬（耐药性关键机制）增强疗效，并利用光声/荧光双模态成像实现精准治疗监测；
➂ 动物实验显示肿瘤显著缩小且无毒性，微流控技术合成的纳米颗粒具备规模化潜力，为临床转化奠定基础。
➀ Researchers developed **PPBC LNPs**, multifunctional nanoparticles integrating photodynamic therapy (PDT), photothermal therapy (PTT), and real-time imaging to combat treatment-resistant bladder cancer;
➁ The nanoparticles demonstrated strong anti-cancer effects by inducing cell death and suppressing autophagy (a resistance mechanism) while enabling high-resolution imaging via photoacoustic and fluorescence modalities;
➂ In vivo trials showed tumor reduction with no toxicity, and scalable microfluidic synthesis supports potential clinical translation for precision medicine.
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