➀ Researchers developed curcumin-loaded HA/CeO2 nanoparticles to improve curcumin's therapeutic efficacy, addressing its poor solubility and low bioavailability. ➁ The nanoparticles showed a uniform size distribution and high encapsulation efficiency, facilitating effective delivery to inflamed tissues. ➂ In vitro and in vivo studies demonstrated the nanoparticles' potential in treating diseases like inflammatory bowel disease, with sustained curcumin release and reduced inflammation.