01/22/2025, 11:28 PM UTC
工程化的DNA-纳米粒子马达实现蛋白质马达的速度Engineered DNA-Nanoparticle Motors Achieve Motor Protein Speeds
<p>➀ 来自分子科学研究所的研究人员通过优化设计提高了DNA-纳米粒子马达的速度，使其更接近自然蛋白质马达的速度。</p><p>➁ DNA-纳米粒子马达使用“烧毁桥”布朗棘轮机制，其中RNA/DNA键的降解推动马达向前运动。</p><p>➂ 通过增加RNase H的浓度，马达的速度得到了显著提升，尽管这以降低运行距离和过程性为代价。</p><p>➀ Researchers from the Institute for Molecular Science have improved the speed of DNA-nanoparticle motors by optimizing their design, bringing them closer to the speeds of natural motor proteins.</p><p>➁ The DNA-nanoparticle motor uses the 'burnt-bridge' Brownian ratchet mechanism, where the degradation of RNA/DNA bonds propels the motor forward.</p><p>➂ By increasing the concentration of RNase H, the speed of the motor was significantly enhanced, though it came at the cost of reduced run length and processivity.</p>
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