03/17/2025, 05:28 PM UTC
通过脂质纳米颗粒方法重编程肝脏免疫：胰腺癌治疗的新策略Reprogramming Liver Immunity: A Lipid Nanoparticle Approach for Pancreatic Cancer Therapy
<p>➀ 研究人员开发了脂质纳米颗粒（LNPs）来递送编码KRAS G12D新抗原和cGAMP的mRNA，以重编程肝脏的免疫环境并生成针对转移性胰腺癌的抗肿瘤反应。</p><p>➁ LNPs成功激活了I型干扰素通路，导致CD8+细胞毒性T细胞的生成，这些T细胞能够识别和攻击转移性癌细胞。</p><p>➂ 研究表明，将KRAS mRNA与STING激动剂结合可以增强针对PDAC的免疫反应，并且比传统的免疫疗法更有效。</p><p>➀ Researchers developed lipid nanoparticles (LNPs) to deliver mRNA encoding the KRAS G12D neoantigen and cGAMP to reprogram the liver's immune environment and generate an antitumor response against metastatic pancreatic cancer.</p><p>➁ The LNPs successfully activated the type I interferon pathway, leading to the generation of CD8+ cytotoxic T cells capable of recognizing and attacking metastatic cancer cells.</p><p>➂ The study suggests that combining KRAS mRNA with a STING agonist strengthens the immune response against PDAC and offers a more effective approach than traditional immunotherapies.</p>
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